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McLean research

Brent P. Forester: Geriatric Mood Disorders Research Program

Cognitive impairment and depression overlap in older adults. Our clinician-scientists aim to better understand the neurobiological causes of mood changes in older adults and translate these findings into more effective, safe, and targeted treatments.

The symptoms of psychiatric illnesses change over the lifespan. Older adults with depression may not experience sadness or hopelessness but instead may feel tired and confused and lack motivation. Major depression and bipolar disorder in later life are often complicated by co-occurring medical disorders and are risk factors for cognitive impairment and suicide. Current treatments are poorly studied in older adults, who have complex medical and cognitive problems.

Our program collects diverse clinical, functional, and biological data on individuals who participate in our studies. This information allows us unique insights into neurobiological changes over the lifespan. We examine multiple factors that affect mental health and wellness and explore how these factors interact with mood disorders.

The Geriatric Mood Disorders Research Program was founded in 2005.