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McLean researchers

Mei-Hua Hall: Psychosis Neurobiology Laboratory

Our scientists are building a neurophysiological profile of the brain that characterizes psychotic disorders, with the goal of identifying the neurobiological mechanisms that correspond to behavioral symptoms. In addition, we are testing a cognitive training program for its effects on the functioning and life skills of patients with schizophrenia.

Robust studies of schizophrenia and bipolar disorder have identified many risk genes and variations within these genes associated with psychotic disorders, though their effects on the brain are largely unknown. We collect a variety of neurophysiological, clinical, and cognitive performance data on patients with psychotic disorders and are building a neurophysiological profile of the brain. Our goals are linking genetic risk factors associated with psychosis disorders to brain neurophysiological characteristics and clarifying the underlying neurobiology of psychotic disorders.

We have developed a computerized cognitive training program for patients with schizophrenia and bipolar disorder with the goal of improving certain cognitive functions (such as memory and attention) and psychosocial outcomes.

The Psychosis Neurobiology Laboratory was founded in 2013.