Every cell in the human brain is surrounded by a lattice of molecules called the extracellular matrix. This matrix regulates how brain cells migrate, mature, and connect. Our group recently found pronounced abnormalities of this matrix in the brains of people with schizophrenia. Those abnormalities might play a fundamental role in the causes or expression of this condition.
Our ongoing work aims to further characterize these and other matrix anomalies in schizophrenia and bipolar disorder, and shed light on related brain mechanisms. Understanding these processes is critical for developing new treatments for psychotic conditions.
The Translational Neuroscience Laboratory was founded in 2000.