Milissa Kaufman, MD, PhD
- Assistant Professor of Psychiatry
Milissa Kaufman, MD, PhD, graduated from the combined MD/PhD program at Boston University. As a doctoral student, she trained with Dr. Terence Keane at the National Center for PTSD in Boston. Her research focused on assessment and treatment of trauma-spectrum disorders including acute stress disorder, post-traumatic stress disorder (PTSD), and the dissociative disorders. Subsequently, she completed a psychiatry residency within the MGH/McLean Adult Psychiatry Residency Training Program, serving as McLean administrative chief resident. During residency, she trained extensively with trauma-spectrum disorders expert Dr. James Chu.
Currently, Dr. Kaufman is the medical director at the Hill Center for Women, a clinical program specializing in the treatment of PTSD. She also is the director of the Dissociative Disorders and Trauma Research Program. She served as the associate training director of the MGH/McLean Psychiatry Residency Training Program from 2012-2014, and currently serves as a teacher, supervisor, and mentor.
The Dissociative Disorders and Trauma Research Program, founded in 2013 and led by Dr. Kaufman, focuses on women with experiences of childhood trauma. Dissociative symptoms are associated with trauma spectrum disorders such as post-traumatic stress disorder (PTSD) and dissociative identity disorder (DID). These symptoms may include memory gaps, feelings of detachment from one’s body, emotions, or environment, confusion over one’s identity, and shifts in one’s identity.
Dr. Kaufman’s group aims to identify and understand the brain mechanisms, cognitions, and genes contributing to PTSD and DID and how they relate to both dysfunction and resilience in these disorders. They examine why some people with experiences of trauma develop dissociative symptoms while others do not, why some develop PTSD and others do not, and what brain regions are involved in dissociative symptoms and how they work.
Using cutting-edge statistical, behavioral, and imaging techniques, Dr. Kaufman’s group explores these areas to determine how to identify those at risk for certain trauma related symptoms, how to better identify those who will respond optimally to a particular treatment, and how to tailor individual treatments for the best recovery outcomes. Ultimately, Dr. Kaufman hopes to develop new treatment approaches for these conditions and reduce the stigma surrounding these disorders. Her research goal is to advance the understanding of the genetic, physiological, neural, cognitive, and behavioral mechanisms that underlie trauma spectrum disorders.
In their work evaluating the neurobiological basis of traumatic dissociation in a cross-diagnostic sample of women with histories of childhood abuse and neglect, Dr. Kaufman and her research program focus on the neurobiology of dissociation in women who have experienced childhood trauma. Dissociation is a common reaction to traumatic experiences. At the time of a traumatic event, it may serve as an adaptive function by buffering the impact of overwhelming sensations, emotions, and cognitions. With repeated traumatic experiences, however, dissociation may become conditioned as a primary coping mechanism and occur chronically in response to reminders of the original traumatic event. This response often generalizes to relatively minor daily events. The neurobiology and genetics of dissociation are largely unknown, and the program’s current work aims to characterize these mechanisms in women with the dissociative subtype of PTSD and with DID.
The group is also studying the neurobiology of PTSD dysfunction and recovery following cognitive processing therapy. Previous research has identified negative alterations in self-cognitions (e.g., shame, perceived worthlessness, incompetence) as a strong predictor of PTSD risk, status, and severity. Negative self-processing is associated with alterations in the neural correlates of self-referential processing (e.g., midline cortical structures) and autobiographical memory systems (e.g., medial temporal lobe structures). Using neuroimaging genetic approaches, Dr. Kaufman aims to examine the relationship between traumatic experiences and the neural mechanisms of negative self-referential processing and determine how this relationship changes during PTSD extinction. Concurrently, the research group is examining how the epigenetic profile of different candidate genes predicts, and perhaps changes, in response to recovery from PTSD (and negative self-cognitions) along with its neural correlates. This understanding will further connect genetic biomarkers of risk with neural intermediate phenotypes underlying PTSD symptomatology.
- Justin T. Baker, MD, PhD, McLean Hospital
- Blaise Frederick, PhD, McLean Hospital
- Shelly F. Greenfield, MD, MPH, McLean Hospital
- Staci Gruber, PhD, McLean Hospital
- Kathryn Kieran, PMHNP-BC, McLean Hospital
- Jean A. King, PhD, Worcester Polytechnic Institute
- Beth Murphy, MD, PhD, McLean Hospital
- Lisa Nickerson, PhD, McLean Hospital
- Kerry J. Ressler, MD, PhD, McLean Hospital
- Isabelle M. Rosso, PhD, McLean Hospital
- Ann K. Shinn, MD, MPH, McLean Hospital
Lewis-Schroeder NF, Kieran K, Murphy BL, Wolff JD, Robinson MA, Kaufman ML. Conceptualization, assessment, and treatment of traumatic stress in first responders: a review of critical issues. Harvard Review of Psychiatry 2018;26(4), 216-227.
Lebois LAM, Wolff JD, Hill SB, Bigony CE, Winternitz S, Ressler KJ, Kaufman ML. Preliminary evidence of a missing self bias in face perception for individuals with dissociative identity disorder. Journal of Trauma and Dissociation 2019;20(2):140-164.
Seligowski AV, Lebois LAM, Hill SB, Kahhale I, Wolff JD, Jovanovic T, Winternitz S, Kaufman ML, Ressler KJ. Autonomic responses to fear conditioning among women with PTSD and dissociation. Depression and Anxiety 2019;36(7):625-634.
Education & Training
- 1990 BS in Psychology, Arizona State University
- 2004 MD, Boston University School of Medicine
- 2004 PhD in Behavioral Neuroscience, Boston University Division of Graduate Medical Sciences
- 2004-2008 Adult Psychiatry Residency Training Program, Massachusetts General Hospital/McLean Hospital
- 2008 Medical License, Board of Registration in Medicine, Commonwealth of Massachusetts
- 2011 Psychiatry, American Board of Psychiatry and Neurology