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Basic Neuroscience Related Content


McLean Hospital Neuroscientists Find Immune System in Newborns May Affect Developing Brain

McLean Hospital neuroscientists have found that even a brief episode of immune system activation within days of birth can cause persistent changes in sleep patterns concurrent with increases in epilepsy-like brain activity—a combination of symptoms common in autism spectrum disorder (ASD) and other developmental conditions. The detailed findings are available in the January 12, 2018 issue...

Recent McLean Research Publications – December 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus Teicher MH, Anderson CM, Ohashi K, Khan A, McGreenery CE, Bolger EA, Rohan ML, Vitaliano GD. NeuroImage. 2017 Dec 27....

Recent McLean Research Publications – November 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Effects of global payment and accountable care on medication treatment for alcohol and opioid use disorders Donohue JM, Barry CL, Stuart EA, Greenfield SF, Song Z, Chernew ME, Huskamp HA. Journal of Addiction Medicine. 2017 Nov 20. [...

Carlezon Agrees to Continue as Neuropsychopharmacology Editor in Chief

Bill Carlezon, PhD, chief of McLean’s Division of Basic Neuroscience and director of the Behavioral Genetics Laboratory, has agreed to continue in his role as editor in chief of Neuropsychopharmacology, the official journal of the American College of Neuropsychopharmacology, until December 31, 2022. In addition to his efforts to attract and publish cutting-edge clinical and preclinical...

Recent McLean Research Publications – October 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior Li S, Kumar T P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R,...

Is Alzheimer’s Disease a Disorder of Energy Metabolism? New Study Shines New Light

A team of investigators from McLean Hospital and Harvard Medical School, led by Kai-Christian Sonntag, MD, PhD, and Bruce M. Cohen, MD, PhD, has found a connection between disrupted energy production and the development of late-onset Alzheimer’s disease (LOAD). The findings appear in the current issue of Scientific Reports. “These findings have several implications for understanding...

McLean Hospital’s Dr. Joseph Coyle Receives Sarnat Award

McLean Hospital’s Joseph T. Coyle, MD, widely renowned for his revolutionary neuroscience research that has led to improved clinical care for those with mental illness worldwide, was honored today by the National Academy of Medicine (NAM) with the 2017 Rhoda and Bernard Sarnat International Prize in Mental Health. The selection of Coyle, who holds the Eben S. Draper Chair of Psychiatry and...

Discovery @ McLean Hospital 2017

Conducting state-of-the-art scientific investigation to maximize discovery and accelerate translation of findings towards achieving prevention and cures is a core element of the McLean Hospital mission. Demonstrating that commitment, we have developed this new publication. This inaugural edition and those to follow will focus exclusively on the cutting-edge research taking place here at McLean...

Personalizing Stem Cell Therapy for Parkinson’s Disease

In the United States alone, as many as one million people have Parkinson’s disease (PD), with approximately 60,000 cases being diagnosed each year, according to the Parkinson’s Disease Foundation. Kwang-Soo Kim, PhD, director of the Molecular Neurobiology Laboratory at McLean Hospital and professor of psychiatry at Harvard Medical School, is committed to finding a way to lower those...

Recent McLean Research Publications – September 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Global/local processing style: explaining the relationship between trait anxiety and binge eating Becker KR, Plessow F, Coniglio KA, Tabri N, Franko DL, Zayas LV, Germine L, Thomas JJ, Eddy KT. International Journal of Eating Disorders...

Recent McLean Research Publications – August 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Working memory and salivary brain-derived neurotrophic factor as developmental predictors of cocaine seeking in male and female rats Jordan CJ, Andersen SL. Addiction Biology. 2017 Aug 31. [Epub ahead of print] GluA4 dependent...

Being Bullied May Dramatically Affect Sleep Suggests New McLean Hospital Research

New research from McLean Hospital neuroscientists shows in an animal model that being bullied can have long-term, dramatic effects on sleep and other circadian rhythm-related functions, symptoms that are characteristic of clinical depression and other stress-induced mental illnesses. The researchers, however, also found that it may be possible to mitigate these effects with the use of an...

Recent McLean Research Publications – July 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Distinct trajectories of cortisol response to prolonged acute stress are linked to affective responses and hippocampal gray matter volume in healthy females Admon R, Treadway MT, Valeri L, Mehta M, Douglas S, Pizzagalli DA. Journal of...

Recent McLean Research Publications – June 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Effects of acute and chronic treatments with dopamine D2 and D3 receptor ligands on cocaine versus food choice in rats Thomsen M, Barrett AC, Butler P, Negus SS, Caine SB. Journal of Pharmacology and Experimental Therapeutics. 2017 Jul;...

McLean Researchers Awarded Allowance for a Method to Treat PTSD and Other Disorders with Xenon Gas

Researchers from McLean Hospital have been issued a patent allowance for their invention involving the use of xenon gas to aid in the treatment of addiction and anxiety disorders such as post-traumatic stress disorder (PTSD). The allowance indicates that, pending administrative actions, a patent will be issued to Edward G. Meloni, PhD, an investigator in the Behavioral Genetics Laboratory at...

Recent McLean Research Publications – May 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine Dall C, Weikop P, Dencker D, Molander AC, Wörtwein G, Conn PJ, Fink-Jensen A, Thomsen M. Drug and Alcohol Dependence. 2017 May 16;176:154-...

Inspiring the Next Generation of Neuroscientists

Have you ever held a human brain in your hands...or ever imagined doing so? Thanks to McLean Hospital’s new educational outreach program, many students around Greater Boston have had the chance not only to hold an actual brain, but also to learn about the inner workings and boundless potential of the mind. Launched in March 2016, the program has brought interactive lessons on neuroscience...

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