Mclean Hospital

Brain Development Related Content


Blood Vessel Development’s Role in Psychiatric Disorders

For decades, scientists have known that gamma-aminobutyric acid (GABA) is a key factor in the development of neuropsychiatric disorders. But recent discoveries in the Angiogenesis and Brain Development Laboratory of Anju Vasudevan, PhD, have literally opened a new pathway. Disruptions in prenatal brain development can lead to disorders such as epilepsy, autism, schizophrenia, and anxiety. The...

McLean Hospital Neuroscientists Find Immune System in Newborns May Affect Developing Brain

McLean Hospital neuroscientists have found that even a brief episode of immune system activation within days of birth can cause persistent changes in sleep patterns concurrent with increases in epilepsy-like brain activity—a combination of symptoms common in autism spectrum disorder (ASD) and other developmental conditions. The detailed findings are available in the January 12, 2018 issue...

Brain Geography: Map Details Newly Identified Regions of the Mind

The human brain is a world unto itself and still holds great potential for discovery. When we describe its structure and functionality, we often refer to the left and right hemispheres and the four lobes—frontal, temporal, occipital, and parietal. There are, however, many smaller, distinct regions within our mind, each with its own specialization. History of Brain Mapping Up to this point...

The Essence of Adolescence: Examining Addiction in the Teenage Brain

When Marisa M. Silveri, PhD, director of McLean Hospital’s Neurodevelopmental Laboratory on Addictions and Mental Health, gives community presentations on the effects of alcohol and drug use on the adolescent brain, she refers to herself as a “neuroscience interpreter.” Speaking to hundreds of students, parents, educators, mental health workers, law enforcement officers, and...

Susan L. Andersen, PhD

Susan L. Andersen, PhD, is director of the Laboratory of Developmental Neuropharmacology at McLean Hospital and an associate professor of psychiatry at Harvard Medical School. She is interested in understanding how the brain typically matures between childhood, adolescence, and adulthood. Her research focuses on how environmental factors, such as drugs of abuse or early adversity, result in...

Jugajyoti Baruah, PhD

Jugajyoti Baruah, PhD, is a post-doctoral fellow in the Angiogenesis and Brain Development Laboratory. Dr. Baruah is currently exploring multiple aspects of neurovascular interactions and signaling that shape brain development with lasting consequences for the mature brain. A particular focus is on understanding the importance of synapse specific gene expression in CNS endothelial cells and its...

Gabriele Chelini, PhD

Gabriele Chelini, PhD, started his career in neuroscience joining a PhD program at the University of Florence, where he acquired expertise in in vitro and in vivo electrophysiology in mouse models of neurodevelopmental disorders. During this training, he spent 8 months with the Hensch-Fagiolini lab at Harvard Medical School, enhancing his understanding of experience-dependent plasticity. During...

Julia E. Cohen-Gilbert, PhD

Julia E. Cohen-Gilbert, PhD, employs cognitive and behavioral measures in conjunction with magnetic resonance imaging and magnetic resonance spectroscopy to investigate the role of brain development in cognitive and emotional regulation during adolescence. She is particularly interested in dynamic prefrontal-limbic interactions that contribute to impulsive or risky behavior in this age group. In...

Staci Gruber, PhD

Dr. Gruber is director of the CCNC and associate professor of psychiatry at Harvard Medical School. Her clinical and research focus is the application of neurocognitive models and multimodal brain imaging to better characterize neurobiological risk factors for substance abuse and psychopathology. Dr. Gruber’s lab has examined the etiologic bases of neural models of dysfunction in patients...

Marisa M. Silveri, PhD

Marisa M. Silveri, PhD, has been studying the neurobiology of brain development and consequences of alcohol and drug abuse using preclinical and clinical models for over two decades. Her current work uses non-invasive magnetic resonance techniques to examine brain structure, function, and neurochemistry, focusing on consequences of alcohol use and abuse. Neurobiological measures are examined...

Martin Teicher, MD, PhD

Martin Teicher, MD, PhD, has been director of the Developmental Biopsychiatry Research Program at McLean Hospital since 1988. He was director of the former Developmental Psychopharmacology Laboratory (now the Laboratory of Developmental Neuropharmacology), and is currently an associate professor of psychiatry at Harvard Medical School. Dr. Teicher is a member of the editorial board of the...

Anju Vasudevan, PhD

Dr. Anju Vasudevan’s work on early embryogenesis of the forebrain vascular system has opened up an entirely new conceptual framework from which to view this important component of brain development. Her research focuses primarily on defining mechanisms governing central nervous system angiogenesis and how it influences key events during brain development, i.e., neurogenesis, neuronal...

T. Wilson Woo, MD, PhD

Dr. Woo’s research interest is in defining the nature of cortical circuitry disturbances in schizophrenia and other psychotic disorders, and in understanding the developmental neurobiological pathways that lead to these disturbances. In addition to his research, Dr. Woo maintains an active clinical practice. His ultimate goal is to translate research findings from the laboratory into...