Mclean Hospital

Bruce Cohen Related Content


In Vitro Cell Culture Findings Could Lead to Novel Interventions for Schizophrenia

A study recently published in Translational Psychiatry, a Nature journal, has shown how using cultured cells from patients with psychotic disorders, such as schizophrenia, to investigate abnormalities in nerve connections in the brain could lead to new treatments. Strong correlations were observed between the findings in the cells in culture—grown outside the body in a controlled environment—and...

Researchers Challenge Genetic Tests for Guiding Psychiatric Treatment

In a paper published in JAMA Psychiatry, McLean Hospital’s Program for Neuropsychiatric Research director Bruce M. Cohen, MD, PhD, and his colleagues, George S. Zubenko, MD, PhD, University of Pittsburgh School of Medicine (retired), and Barbara R.M. Sommer, MD, Stanford University School of Medicine, emerita, reviewed the scientific basis and effectiveness of pharmacogenetic (Pgen) tests in...

Is Alzheimer’s Disease a Disorder of Energy Metabolism? New Study Shines New Light

A team of investigators from McLean Hospital and Harvard Medical School, led by Kai-Christian Sonntag, MD, PhD, and Bruce M. Cohen, MD, PhD, has found a connection between disrupted energy production and the development of late-onset Alzheimer’s disease (LOAD). The findings appear in the current issue of Scientific Reports. “These findings have several implications for understanding and...

Are We Looking at Psychiatric Disorders the Wrong Way?

The first psychiatric patient I evaluated—42 years ago—presented with delusions and mood swings. Based on those symptoms, our attending physician diagnosed her with schizoaffective disorder. We medical clerks were confused by that assessment. Schizoaffective disorder encompasses a combination of symptoms of schizophrenic and mood disorders, and such a mixed diagnosis seemed like a violation of...

Bruce Cohen is Recipient of the 2016 Outstanding Psychiatrist Award for Research from the MPS

Bruce M. Cohen, MD, PhD, director of McLean’s Program for Neuropsychiatric Research, Robertson-Steele professor of psychiatry at Harvard Medical School, and president and psychiatrist in chief emeritus of McLean, is the recipient of the 2016 Outstanding Psychiatrist Award for Research from the Massachusetts Psychiatric Society (MPS). Cohen, whose career at McLean spans 40 years, was recognized...

Faces in the Crowd—99 of Them

In viewing the 99 Faces Project—a diverse collection of portraits featuring people impacted by mental illness—it’s indistinguishable as to who are on the schizophrenia spectrum, who are on the bipolar spectrum, and who are the ones who love them. The diversity in age, gender, and ethnicity of the 33 participants in each category helps raise awareness that mental illness can affect anyone at any...

Understanding the Brain’s “Suffocation Alarm”

Panic disorder is a severe form of anxiety in which the affected individual feels an abrupt onset of fear, often accompanied by profound physical symptoms of discomfort. Scientists have known from studying twins that genes contribute to the risk of panic disorder, but very little is known about which specific genes are involved. Two of the most common and terrifying symptoms of this severe...

McLean Hospital Researchers Find Inherited Pathway of Risk for Schizophrenia

Schizophrenia is one of the most disabling of all psychiatric illnesses. Sadly, it is not uncommon and it strikes early in life. Many studies have looked into causes and potential interventions, and it has been long known that genetic factors play a role in determining the risk of developing schizophrenia. However, recent work has shown that there will be no simple answers as to why some people...