Mclean Hospital

Translational Research Related Content


7th Annual McLean Research Day Draws More than 200 Participants

More than 200 researchers and clinicians attended the seventh annual McLean Research Day on January 20 to learn about the latest scientific investigations and discoveries being made across the hospital. Details of new research projects were displayed on 121 posters representing basic science, translational, clinical, neuroimaging, health services, and implementation science research pertaining...

Crossing Borders: McLean and the Chinese Society of Psychiatry Forge Collaboration

In October 2015, researchers from McLean Hospital, Harvard Medical School, and the Chinese Society of Psychiatry convened on McLean’s Belmont campus, marking the first meeting of the new McLean Hospital-Chinese Society of Psychiatry Initiative in Psychiatry (MCIP). Established to foster collaborations among clinician-investigators specializing in major psychotic and mood disorders and the...

Improving Lives Through Innovative Translational Research

Scientists at McLean Hospital are gaining more insight into the causes of mental illness, neuropsychiatric disorders, and neurodevelopmental disorders by using cutting-edge approaches and technology to manipulate pathways and circuits in the brains of animals that produce behaviors similar to humans. “McLean is at the forefront of building new treatments and interventions based on our...

Donors Fuel Research Into Depression, World’s Leading Cause of Disability

For much of the last century, depression has been viewed largely as a single disease; however, it is an extraordinarily heterogeneous condition. Consequently, predicting which healthy people will develop depression is challenging. Given that approximately half of patients do not respond to current options for care, finding the right treatment is equally difficult. Clearly, further study is needed...

Supporting New Discoveries in Psychiatry

Thanks to a recent gift from Patricia and James Poitras to establish the James and Patricia Poitras Endowed Chair in Psychiatry, McLean Hospital has recruited world-renowned clinician-researcher Kerry J. Ressler, MD, PhD, as the new Chief Scientific Officer. As an expert in fear-based disorders, Dr. Ressler’s research examines how fear works in the mammalian brain at cellular and molecular...

Individuals in Psychiatric Treatment Want Spirituality and Religion Integrated Into Their Care, Reports McLean Hospital

A new study conducted by researchers at McLean Hospital indicates nearly 60 percent of patients have significant interest in integrating spirituality and religion into their mental health care. According to the study, published October 1 in the Journal of Consulting & Clinical Psychology, 58.2 percent of patients reported “fairly or greater” interest in spiritually-integrated...

Capturing Data Shapes Programs at Home and Spurs Research Worldwide

At McLean Hospital, embedding behavioral health research in the clinical setting simultaneously enhances patient care and brings valuable treatment advances to the attention of the scientific community. Spearheading this unique approach at McLean are Courtney Beard, PhD, who serves as assistant director of research in the Behavioral Health Partial Hospital Program (BHP), and Jason Elias, PhD,...

Collaborative Science: Probing Genetic Connections Leads to Successful New Treatments

Collaboration is key to research at McLean, leading to landmark findings that go beyond the sum of the parts. Deborah L. Levy, PhD, director of the Psychology Research Laboratory, recently led one such meeting of the minds. Working closely with Laura Godfrey, RPh, J. Alexander Bodkin, MD, Michael Coleman, and other colleagues, Levy ran the first treatment intervention in psychiatry tailored to a...

Study of OCD Patients Shows that Motivation to Change is an Indicator in Treatment Outcome

A patient's level of motivation and preparedness to change significantly impacts the outcome of treatment, a study conducted at McLean Hospital's Obsessive Compulsive Disorder Institute (OCDI) has found. Data from 424 patients who underwent treatment at the OCDI since 2009 show a direct correlation between their readiness to change and their outcomes in terms of modifying behaviors, according to...

Frank Tarazi is Helping to Develop International Plans for Investments into Brain Health

Earlier this year, Frank Tarazi, MBBS, PhD, MBA was appointed to the Global Agenda Council on Brain Research, joining 17 other prominent leaders in the fields of academia, business, economics, medicine, and science to collaborate and develop business plans that will aim to generate new investments worldwide into brain research. The newly-convened council was created by the World Economic Forum (...

Longtime Supporters Bring World Class Research Leader to McLean

For longtime donors and McLean National Council members Pat and Jim Poitras, supporting new discoveries in psychiatry has been a common thread in their philanthropy. That is why they have, for many years, invested in research at McLean Hospital. Their most recent gift to McLean—and largest at $4 million—established the Patricia and James Poitras Endowed Chair in Psychiatry at McLean...

New Survey Will Guide OCD Research and Care

In the OCD Institute Office of Clinical Assessment and Research, we have implemented several new data collection initiatives this year, including efforts to collect information from the family members of patients. Earlier this year, we began contacting family members by email with a link to an online survey. The family member to whom the email is sent is designated by the patient when they...

Potential New Treatment for PTSD Discovered

McLean Hospital researchers are reporting that xenon gas, used in humans for anesthesia and diagnostic imaging, has the potential to be a treatment for post-traumatic stress disorder (PTSD) and other memory-related disorders. “In our study, we found that xenon gas has the capability of reducing memories of traumatic events,” said Edward G. Meloni, PhD, assistant psychologist at...

Pope-Hintz Fellowship Fosters Next Generation of Clinician-Researchers

McLean National Council members Edward and Helen Hintz want to ensure training opportunities for dually skilled clinician-researchers for generations to come. They established the Pope-Hintz Endowed Fellowship in honor of Harrison “Skip” Pope Jr., MD, MPH, to do just that. For 25 years, Dr. Pope has been a beacon of hope for the Hintz family, advising them through crises and periods...

Inspiring Hope Through Research

As a trained certified public accountant (CPA), Raquel Espinosa followed a unique path to McLean, where she oversees the hospital’s Research Administration Department. However, the detail-oriented work involved in becoming a CPA turns out to have been a perfect training ground for Espinosa, who uses her love of numbers and details each day to provide infrastructural support for the hospital...

Increasing Access to Care Through Innovation

Kathryn McHugh, PhD, is determined to increase access to quality mental health care for people in need. Through her research to improve the effectiveness of behavioral therapies and innovative treatment delivery models, such as computer-based treatments, she hopes to address the public health crisis of untreated mental illness across the United States. Kathryn McHugh, PhD“I have seen how...

Growing, Innovating, and Improving: Update on OCD Research

The Office of Clinical Assessment and Research (OCAR) experienced a growth spurt recently and now features seven core members. I have asked Jesse Crosby, PhD, to lead this expanded team and coordinate our effort to do everything we can to help patients recover from OCD and related disorders. In this update, I have highlighted several important areas of opportunity for OCAR and what it could mean...

Religious Coping Positively Affects Individuals with Severe Psychiatric Illness

The use of religious coping has been shown to significantly improve the treatment outcomes of those receiving short-term treatment for psychiatric illness, according to a recent study conducted by McLean Hospital investigators. In the study (PMID: 23684053), published in the current issue of Psychiatry Research, David H. Rosmarin, PhD, McLean Hospital clinician and instructor in the Department...

Bringing Trauma to Light

Emotional trauma has long been a part of the human experience, but it has only been in recent decades that we have begun to comprehend and study its effects. “We owe much of our current understanding about the impact of trauma to the difficulties faced by soldiers returning from the Vietnam War,” said Milissa Kaufman, MD, PhD, medical director of the trauma-focused Hill Center for...

McLean Hospital Researcher Says Intensive, Early Therapy Helps Children with Autism Improve Communication Skills

In an article appearing in the October issue of Scientific American, McLean Hospital biostatistician Nicholas Lange, ScD, asserts that although the road to more accurate diagnosis and treatment of a disease as complex as autism is long, some existing therapies are already showing lasting effects, and more are on the horizon. “Autism is a complex disease with multiple causes, differing...

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