Mclean Hospital

Video: The Circuits That Underlie Deep Brain Stimulation Targets for OCD

Available with English captions.

Suzanne N. Haber, PhD, Jason Krompinger, PhD, McLean Hospital – Crossroads in Psychiatry Lecture

Deep brain stimulation is a promising therapeutic approach for patients with treatment-resistant obsessive compulsive disorder (OCD), a condition linked to abnormalities in cortico-basal ganglia networks in the brain.

Effective targets are placed in one of four subcortical areas with the goal of capturing prefrontal, anterior cingulate, and basal ganglia connections linked to the limbic system. These include the anterior limb of the internal capsule, the ventral striatum, the subthalamic nucleus, and a midbrain target.

In this presentation Drs. Suzanne Haber and Jason Krompinger review the circuits most often associated with OCD and, using a combination of nonhuman primate anatomy and diffusion MRI in both nonhuman primates and humans, examines the four targets with respect to the similarities and differences of their connections.

Drs. Haber and Krompinger help us to:

  • Identify brain structures and circuits involved in OCD
  • Identify the circuits effected by deep brain stimulation (DBS) for OCD.
  • Understand how anatomy can inform diffusion MRI studies and help focus DBS targets
  • Describe the role that understanding neurobiological bases of OCD plays in helping patients make sense of their condition
  • Explain how the “COD” model of conceptualizing OCD may help patients understand ego-dystonic experiences
  • Discuss ways that seeing OCD as a biological brain disorder can help patients access core processes in augmentative treatment such as acceptance and commitment therapy
January 28, 2021

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