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McLean Researchers Lead ECT Study for Alzheimer’s Patients With Aggression

Researchers at McLean Hospital will lead a five-year study to investigate the use of electroconvulsive therapy (ECT) to treat severe agitation and aggression in people with Alzheimer’s disease. The study was made possible by a five-year grant, expected to total $11.8 million, from the National Institute on Aging (NIA) under award number R01AG06110001. Part of the National Institutes of...

New Smartphone App Helps During Mental Health Treatment Transition

The transition out of an inpatient psychiatric setting is never easy—for the patient or the clinician. And the challenge escalates after the day program ends and the patient returns home. Now, clinicians at McLean Hospital’s Behavioral Health Partial Hospital Program (BHP), a day program that integrates psychotherapy and pharmacotherapy (medications), believe they have a way to...

Brain Wiring Helps Illuminate Range of Uses for Non-Drug Therapies

Imagine if depression or obsessive compulsive disorder (OCD) could be treated with non-drug therapies, such as those currently being used to tackle Parkinson’s disease and other movement disorders. Suzanne Haber, PhD, is working toward that goal in her labs at McLean Hospital and the University of Rochester Medical Center. For the moment, the research focus is “to understand how the...

Discovery @ McLean Hospital 2018

This edition of Discovery demonstrates some of the depth and breadth of research at McLean Hospital. With hundreds of hardworking researchers who hail from all parts of the world, our robust research program has all the tools to bring research from the bench to the bedside. There is much more transformative research that we couldn’t include in this issue, including the ongoing work in the...

Foundation Gift Enables Cannabis Research

For a substance that has been used by humans for more than 5,000 years, there remains much to learn about marijuana’s effects on the brain. McLean neuroscientist and clinical researcher Staci Gruber, PhD, has spent more than two decades trying to advance knowledge in this domain. Now, with the help of a $1.5 million grant from the Patricia Cornwell Foundation, a nonprofit organization...

2018-2019 McLean Fellowship Awardees

McLean Hospital has announced the recipients of 12 fellowships for the 2018-2019 academic year. These fellowships are made possible through a combination of generous support from donors and internal funding resources. McLean Hospital is grateful to its donors, whose philanthropic investments exemplify their trust in the talented investigators listed below who are helping to advance the field of...

Algorithm Identifies Patients Best Suited for Antidepressants

McLean Hospital researchers have completed a study that sought to determine which individuals with depression are best suited for antidepressant medications. Their findings, published in Psychological Medicine on July 2, 2018, have led to the development of a statistical algorithm that identifies patients who may best respond to antidepressants—before they begin treatment. Results of this...

Study on Social Interactions Could Improve Understanding of Mental Health Risks

McLean Hospital investigators have released the results of a study that outlines how age, socioeconomic status, and other factors might contribute to social isolation and poorer mental health. In a paper published in the online version of Clinical Psychological Science, the researchers examine how individuals of all ages and walks of life seek and enjoy social interactions. Because studies have...

Recent McLean Research Publications – May 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Improving adherence to Mediterranean-style diet with a community culinary coaching program: methodology development and process evaluation Polak R, Pober D, Morris A, Arieli R, Moore M, Berry E, Ziv M. The Journal of Ambulatory Care...

Recent McLean Research Publications – April 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Increases in emotional intelligence after an online training program are associated with better decision-making on the Iowa Gambling Task Alkozei A, Smith R, Demers LA, Weber M, Berryhill SM, Killgore WDS. Psychological Reports. 2018...

McLean Scientists: Brain Activity Can Predict Success of Depression Treatment

McLean Hospital and Harvard Medical School researchers believe they have uncovered a method that could be useful in predicting a depressed patient’s treatment prognosis, prior to starting treatment. In the paper “Pretreatment Rostral Anterior Cingulate Cortex Activity in Relation to Symptom Improvement in Depression: A Randomized Clinical Trial,” available online and in the...

Recent McLean Research Publications – March 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Recurrence of task-related electroencephalographic activity during post-training quiet rest and sleep Murphy M, Stickgold R, Parr ME, Callahan C, Wamsley EJ. Scientific Reports. 2018 Mar 29;8(1):5398. Suicidal thoughts and behaviors...

Recent McLean Research Publications – February 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Rostral anterior cingulate cortex morphology predicts treatment response to internet-based cognitive behavioral therapy for depression Webb CA, Olson EA, Killgore WDS, Pizzagalli DA, Rauch SL, Rosso IM. Biological Psychiatry Cognitive...

Recent McLean Research Publications – January 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Fear extinction recall modulates human frontomedial theta and amygdala activity Sperl MFJ, Panitz C, Rosso IM, Dillon DG, Kumar P, Hermann A, Whitton AE, Hermann C, Pizzagalli DA, Mueller EM. Cerebral Cortex. 2018 Jan 24. [Epub ahead of...

Recent McLean Research Publications – December 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus Teicher MH, Anderson CM, Ohashi K, Khan A, McGreenery CE, Bolger EA, Rohan ML, Vitaliano GD. NeuroImage. 2017 Dec 27....

Recent McLean Research Publications – November 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Effects of global payment and accountable care on medication treatment for alcohol and opioid use disorders Donohue JM, Barry CL, Stuart EA, Greenfield SF, Song Z, Chernew ME, Huskamp HA. Journal of Addiction Medicine. 2017 Nov 20. [...

Recent McLean Research Publications – October 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior Li S, Kumar T P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R,...

Discovery @ McLean Hospital 2017

Conducting state-of-the-art scientific investigation to maximize discovery and accelerate translation of findings towards achieving prevention and cures is a core element of the McLean Hospital mission. Demonstrating that commitment, we have developed this new publication. This inaugural edition and those to follow will focus exclusively on the cutting-edge research taking place here at McLean...

Recent McLean Research Publications – September 2017

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Global/local processing style: explaining the relationship between trait anxiety and binge eating Becker KR, Plessow F, Coniglio KA, Tabri N, Franko DL, Zayas LV, Germine L, Thomas JJ, Eddy KT. International Journal of Eating Disorders...

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