Translational Research Related Content

Clinical Trial Tests Novel Stem-Cell Treatment for Parkinson’s Disease

A recently launched Phase 1 clinical trial at Mass General Brigham is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson’s disease in which a patient’s stem cells are reprogrammed to replace dopamine cells in the brain damaged by the disease. The first-of-its...

New Insights Into Trauma-Related Intrusive Memories in PTSD

Trauma-related intrusive memories (TR-IMs)—memories related to a traumatic event that come to mind spontaneously—are central symptoms of post-traumatic stress disorder (PTSD) and may be critical treatment targets for PTSD. Their frequency and intensity are usually measured with retrospective reports...

Streamlined Approach To Equipping Medical Students With Naloxone

Naloxone is now the standard of care for reversing opioid overdoses. However, the stigma about naloxone among health care professionals poses a significant barrier to its distribution. In addition, even medical students who learn to prescribe it and train patients in its use may harbor uncertainty...

A Living Lab for Dementia Caregivers

A wife had been caring for her husband with dementia at home for four years. She had come to McLean’s geriatric outpatient clinic to find out where to get more help for him. But it soon became apparent that she needed help herself. She was lonely and struggling with making decisions on her own. Her...

Researchers Discover a Significant Problem in Brain Imaging, Identify Fix

In a new study, investigators from McLean Hospital (a member of Mass General Brigham), Harvard Medical School, and the National Institute on Drug Abuse Intramural Research Program (NIDA-IRP) discovered that the tendency of people’s arousal to wane over the course of brain scans has been distorting...

Pilot Study Assesses Online Education as First Step for BPD Treatment

Psychoeducation is a common feature of effective treatments for borderline personality disorder (BPD), as patients need to understand the illness and the problems for which their treatments are prescribed. Lois W. Choi-Kain, MD, MEd, director of the Gunderson Personality Disorders Institute at...

Study Uncovers Cell Type-Specific Genetic Insights Underlying Schizophrenia

Schizophrenia is a complex disease with variable presentations. The diverse nature of this mental health disorder has made understanding the mechanisms that cause the disease, and subsequently developing effective treatments, especially challenging. In a new study published May 23 in Science, a team...