Lecture – Personalizing Psychiatric Neuromodulation

Available with English captions.

Shan H. Siddiqi, MD, Beth Israel-Deaconess Medical Center – Visiting Scholar Series

Treatment-resistant psychiatric disorders are often treated with neuromodulation techniques, such as transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and ablative neurosurgery.

These treatments can focally modulate brain circuits. However, our approach to targeting these circuits remains imprecise, which limits clinical utility of neuromodulation.

This lecture focuses on novel approaches to individualizing neuromodulation targets based on clinical subtyping and individualized functional imaging.

Presentation highlights include:

  • Description of current indications for clinical TMS
  • Discussion of subtyping patients based on circuit-based phenotypes in addition to traditional diagnostic categories
  • Examination of predicting response to different circuit-based interventions