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The Harvard Brain Tissue Resource Center (HBTRC), established at McLean Hospital in 1978 and known as the Brain Bank, is a centralized resource for the collection and distribution of human brain specimens for brain research. The Brain Bank collects brain and tissue samples from across the United States and distributes them to investigators all over the world.
A brain donation is a gift of knowledge to all of us, and it is of critical importance for our understanding of brain disorders.
Studies on the human brain are essential to discovering the biological causes of brain disorders. They provide unique access to the brain at the molecular and cellular level, thus allowing researchers to increase our knowledge of changes that happen in the brains of people struggling with these disorders. Such knowledge is critical to prevention and development of new therapeutic treatments.
Scientists from top academic and medical centers request tissue from the Brain Bank for their research. Since the majority of these studies can be carried out on a very small amount of tissue, each donated brain provides a large number of samples for many researchers. However, in order to conduct valid experiments, it is necessary to supply researchers with a variety of brain specimens.
The HBTRC is part of the NeuroBioBank, which is funded by the National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke, and Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Phone: 800.BRAINBANK (800.272.4622)
Becoming a prospective tissue donor is easy. Any person 18 years of age or older can donate.
Once complete, the form can be returned either through the mail or by fax:
Harvard Brain Tissue Resource Center
115 Mill Street, Mail Stop 138
Belmont, MA 02478
If you have registered for potential brain donation at the Brain Bank, it is most important to inform your family and make sure they know to call us (immediately) at the time of your death. We must rely on your legal next of kin/legally authorized representative to contact the Brain Bank in order to follow through on your request to donate your brain.
Being registered as a donor with the Brain Bank is not needed to proceed with a brain donation. However, it is often a good way to let your family and caretakers know about your intentions.
At the time of the death of a potential donor, the legal next of kin will need to be available to review and sign an informed legal consent for the donation to the Brain Bank. This is because an individual’s body becomes the property of their estate at the time of their death.
A registration for brain donation can be withdrawn at any time by writing to the HBTRC.
The Brain Bank gratefully accepts brain donations from people diagnosed with various brain disorders as well as from individuals not affected by these disorders. We accept donations from individuals with conditions such as the ones listed below.
Sabina Berretta, MD, Director
Dr. Berretta is an associate professor of psychiatry at Harvard Medical School. She received her MD from the University of Catania in Italy, before moving to the Massachusetts Institute of Technology in 1990. Dr. Berretta joined McLean Hospital in 1997. Her primary research interest is the pathophysiology of schizophrenia and bipolar disorder. In particular, she focuses on the disruption of the interactions between neurons, glial cells, and extracellular matrix in these disorders.
The Brain Bank team is dedicated to advancing the study of the human brain and to fostering the future of psychiatry and medicine by supporting every step of the brain donation process. From compassionate communication with donors and their families to coordination with pathologists to compiling and facilitating robust clinical information for every tissue sample in the Brain Bank collection in order to aid future research, the staff at the Brain Bank is committed to excellence.
The important work that we do at the Brain Bank could not be accomplished without the assistance of pathologists across the country.
Currently, there is a growing need for tissue from individuals diagnosed with psychiatric and neurological disorders, and from non-affected subjects. Pathologists are urged to encourage families to donate. A neuropathology report will be provided to both the family and the pathologist (upon authorization by the legal next of kin).
The Brain Bank has established specific requirements surrounding body refrigeration, brain removal, packaging, and shipment. We provide detailed instructions as needed, including this packet of protocols and forms.
The Harvard Brain Tissue Resource Center is funded by the National Institutes of Health (NIH), as well as several private organizations, to serve as a vital resource for the collection and distribution of postmortem brain tissues for medical research into the causes of devastating neurological and psychiatric disorders. All tissue diagnoses are confirmed by retrospective review of clinical records and a comprehensive neuropathological examination.
All disbursements from HBTRC are made at no cost to the recipient laboratory. Tissue samples are available in the following preparations:
The NeuroBioBank, a NIH-funded repository of human brain tissue and associated clinical data, was established in September 2013 as a national, centralized resource so that investigators could obtain high-quality, postmortem human brain tissue and further the understanding of the neurological basis for mental disorders.