Mclean Hospital

Basic Neuroscience Related Content


Discovery @ McLean Hospital 2018

This edition of Discovery demonstrates some of the depth and breadth of research at McLean Hospital. With hundreds of hardworking researchers who hail from all parts of the world, our robust research program has all the tools to bring research from the bench to the bedside. There is much more transformative research that we couldn’t include in this issue, including the ongoing work in the...

Brain Wiring Helps Illuminate Range of Uses for Non-Drug Therapies

Imagine if depression or obsessive compulsive disorder (OCD) could be treated with non-drug therapies, such as those currently being used to tackle Parkinson’s disease and other movement disorders. Suzanne Haber, PhD, is working toward that goal in her labs at McLean Hospital and the University of Rochester Medical Center. For the moment, the research focus is “to understand how the...

Ross J. Baldessarini, MD: Celebrating a Pioneer

Ross J. Baldessarini, MD, originally thought he wanted to be an industrial organic chemist, not a doctor. The prospect of medical school didn’t thrill the Williams College chemistry major. He found it to be more like a trade school than an academic endeavor, not to mention it being “cutthroat and nasty.” But after a company he worked for one summer laid off 80 percent of its...

Blood Vessel Development’s Role in Psychiatric Disorders

For decades, scientists have known that gamma-aminobutyric acid (GABA) is a key factor in the development of neuropsychiatric disorders. But recent discoveries in the Angiogenesis and Brain Development Laboratory of Anju Vasudevan, PhD, have literally opened a new pathway. Disruptions in prenatal brain development can lead to disorders such as epilepsy, autism, schizophrenia, and anxiety. The...

New Collaboration Seeks to Understand Trauma’s Impact on Genes

Why does one person who suffered severe childhood adversity become homeless or addicted, while another with a similar background builds a loving family life and a thriving career? Is the answer in our genes, or perhaps in how trauma affects our genes? A collaboration between McLean Hospital and The Connor Group Kids and Community Partners, an Ohio-based non-profit, is attempting to answer this...

Kelsey Fellowship Brings Bates Undergrads to McLean Labs

Former Board Chair David Barlow has endowed a fellowship that forges a closer relationship between two institutions that are dear to his heart: McLean Hospital and his alma mater, Bates College. The John Kelsey Fellowship is named after the retired Bates professor who built the college’s neuroscience program and nurtured generations of neuroscientists, including Bill Carlezon, PhD, chief...

Natalia Luchkina, PhD, Represents McLean at Annual Gathering of Nobel Laureates

McLean Hospital Research Fellow Natalia V. Luchkina, PhD, took part in the annual Lindau Nobel Laureate Meeting in Lindau, Germany, this past June. Established in 1951, this event provides undergraduates, PhD candidates, and post-doctoral researchers with the opportunity to listen and learn from Nobel Prize recipients in fields such as physiology, medicine, physics, and chemistry. This year, the...

2018-2019 McLean Fellowship Awardees

McLean Hospital has announced the recipients of 12 fellowships for the 2018-2019 academic year. These fellowships are made possible through a combination of generous support from donors and internal funding resources. McLean Hospital is grateful to its donors, whose philanthropic investments exemplify their trust in the talented investigators listed below who are helping to advance the field of...

McLean Investigators Suggest That Specific Brain Circuits Could Unlock New Psychiatric Treatments

A McLean Hospital scientific team’s comprehensive analysis of recent research into how the brain shapes responses to cognitive and emotional challenges has revealed the potential for new brain treatments for psychiatric conditions that target specific brain circuits. The detailed review, “An Emerging Circuit Pharmacology of GABAA Receptors,” is available online in the journal...

Recent McLean Research Publications – May 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Improving adherence to Mediterranean-style diet with a community culinary coaching program: methodology development and process evaluation Polak R, Pober D, Morris A, Arieli R, Moore M, Berry E, Ziv M. The Journal of Ambulatory Care...

Opioid Addiction: Exploring Scientific Solutions

The ultimate solution to the opioid crisis is answering the question of what causes addiction and whether it is possible to treat it more effectively or even prevent it. That’s the challenge Elena H. Chartoff, PhD, is taking on in her laboratory. As director of the Neurobiology of Motivated Behavior Laboratory at McLean Hospital, she is exploring the mechanisms that connect depression and...

Recent McLean Research Publications – April 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Increases in emotional intelligence after an online training program are associated with better decision-making on the Iowa Gambling Task Alkozei A, Smith R, Demers LA, Weber M, Berryhill SM, Killgore WDS. Psychological Reports. 2018...

Recent McLean Research Publications – March 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Recurrence of task-related electroencephalographic activity during post-training quiet rest and sleep Murphy M, Stickgold R, Parr ME, Callahan C, Wamsley EJ. Scientific Reports. 2018 Mar 29;8(1):5398. Suicidal thoughts and behaviors...

Neuroscientists Reveal How Brain Circuits Are Affected by Infections in Mothers and Newborns

McLean Hospital neuroscientists have found that immune system activation during pregnancy and right at birth can cause alterations in an offspring's brain neural circuits during young adulthood that are consistent with behavioral symptoms common in autism spectrum disorder (ASD) and other developmental conditions. The detailed findings are available in the March 28, 2018, issue of the Journal of...

Brain Donation for Mental Health Research: Why Do We Need Healthy Brains?

We usually don’t think about our brains when considering organ donation. We are more apt to think about how our other organs, such as the kidneys, lungs, or heart, could potentially save the life of another person. A donated brain, however, also has tremendous potential to help others. Through research, donated human brains have helped us achieve great gains in furthering our understanding...

Recent McLean Research Publications – February 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Rostral anterior cingulate cortex morphology predicts treatment response to internet-based cognitive behavioral therapy for depression Webb CA, Olson EA, Killgore WDS, Pizzagalli DA, Rauch SL, Rosso IM. Biological Psychiatry Cognitive...

National Eating Disorders Brain Bank Will Contribute to Mental Health Research and Care

McLean Hospital’s Harvard Brain Tissue Resource Center (HBTRC) and the Foundation for Research and Education in Eating Disorders (FREED), an organization dedicated to helping determine the causes and risk factors associated with eating disorders, have partnered to establish the first and only national brain bank dedicated to research into eating disorders—the National Eating Disorders...

Recent McLean Research Publications – January 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Fear extinction recall modulates human frontomedial theta and amygdala activity Sperl MFJ, Panitz C, Rosso IM, Dillon DG, Kumar P, Hermann A, Whitton AE, Hermann C, Pizzagalli DA, Mueller EM. Cerebral Cortex. 2018 Jan 24. [Epub ahead of...

McLean Hospital Neuroscientists Find Immune System in Newborns May Affect Developing Brain

McLean Hospital neuroscientists have found that even a brief episode of immune system activation within days of birth can cause persistent changes in sleep patterns concurrent with increases in epilepsy-like brain activity—a combination of symptoms common in autism spectrum disorder (ASD) and other developmental conditions. The detailed findings are available in the January 12, 2018 issue...

Pages