Mclean Hospital

Basic Neuroscience Related Content


McLean Receives $13.5 Million NIMH Grant for Translational Stress Research

The National Institute of Mental Health (NIMH) has awarded a $13.5 million grant to a team of McLean Hospital investigators to support their research into stress chemicals and circuits in the brain. According to Bill Carlezon, PhD, chief of McLean’s Basic Neuroscience Division and one of the lead researchers, the Silvio O. Conte Center for Translational Mental Health Research at McLean Hospital...

Neuroscience Outreach Program Shows Why Brains Matter

Although the brain is central to all that we do, sense, and feel, it’s surprising how little most of us know about how the brain works. That’s why a group of us at McLean Hospital created Brains Matter—an educational neuroscience outreach program. By bringing our expertise—along with actual brain samples—to classrooms, meetings, and public events, we hope to increase understanding of the brain...

Inspired by the Tradition of Women Leaders at McLean

Every day on the job, Dawn Morrissey draws inspiration from McLean Hospital’s past. “When I walk through the hallway leading to the Administration Building on my way to meetings, I always look at the pictures on the wall of the female nurses, doctors, and scientists who have worked at McLean over the years,” she said. “These are women—like Emma Mooers, MD, the first female researcher at McLean,...

McLean Celebrates Women’s History Month

1,631 of McLean’s 2,369 employees are women. McLean is proud of the contributions women make each day to ensure that the hospital delivers compassionate psychiatric care, innovative research, and unparalleled public and professional education throughout the United States and beyond. These women are just a small sample of our female staff members and the work they do every day. Join us in...

Inspiring Hope Through Research

As a trained certified public accountant (CPA), Raquel Espinosa followed a unique path to McLean, where she oversees the hospital’s Research Administration. However, the detail-oriented work involved in becoming a CPA turns out to have been a perfect training ground for Espinosa, who uses her love of organizational and financial management to oversee the research infrastructural support for 150...

Your Genes and Addiction

Dr. Maria Mavrikaki contends we need to understand the triggers for the development of addiction in order to develop more targeted prevention and treatments.

In Vitro Cell Culture Findings Could Lead to Novel Interventions for Schizophrenia

A study recently published in Translational Psychiatry, a Nature journal, has shown how using cultured cells from patients with psychotic disorders, such as schizophrenia, to investigate abnormalities in nerve connections in the brain could lead to new treatments. Strong correlations were observed between the findings in the cells in culture—grown outside the body in a controlled environment—and...

Discovery @ McLean Hospital 2018

This edition of Discovery demonstrates some of the depth and breadth of research at McLean Hospital. With hundreds of hardworking researchers who hail from all parts of the world, our robust research program has all the tools to bring research from the bench to the bedside. There is much more transformative research that we couldn’t include in this issue, including the ongoing work in the Center...

Brain Wiring Helps Illuminate Range of Uses for Non-Drug Therapies

Imagine if depression or obsessive compulsive disorder (OCD) could be treated with non-drug therapies, such as those currently being used to tackle Parkinson’s disease and other movement disorders. Suzanne Haber, PhD, is working toward that goal in her labs at McLean Hospital and the University of Rochester Medical Center. For the moment, the research focus is “to understand how the brain is...

Ross J. Baldessarini, MD: Celebrating a Pioneer

Ross J. Baldessarini, MD, originally thought he wanted to be an industrial organic chemist, not a doctor. The prospect of medical school didn’t thrill the Williams College chemistry major. He found it to be more like a trade school than an academic endeavor, not to mention it being “cutthroat and nasty.” But after a company he worked for one summer laid off 80% of its scientists following a...

Blood Vessel Development’s Role in Psychiatric Disorders

For decades, scientists have known that gamma-aminobutyric acid (GABA) is a key factor in the development of neuropsychiatric disorders. But recent discoveries in the Angiogenesis and Brain Development Laboratory of Anju Vasudevan, PhD, have literally opened a new pathway. Disruptions in prenatal brain development can lead to disorders such as epilepsy, autism, schizophrenia, and anxiety. The...

New Collaboration Seeks to Understand Trauma’s Impact on Genes

Why does one person who experienced severe childhood adversity become homeless or addicted, while another with a similar background builds a loving family life and a thriving career? Is the answer in our genes, or perhaps in how trauma affects our genes? A collaboration between McLean Hospital and The Connor Group Kids and Community Partners, an Ohio-based non-profit, is attempting to answer...

Kelsey Fellowship Brings Bates Undergrads to McLean Labs

Former Board Chair David Barlow has endowed a fellowship that forges a closer relationship between two institutions that are dear to his heart: McLean Hospital and his alma mater, Bates College. The John Kelsey Fellowship is named after the retired Bates professor who built the college’s neuroscience program and nurtured generations of neuroscientists, including Bill Carlezon, PhD, chief of...

Natalia Luchkina, PhD, Represents McLean at Annual Gathering of Nobel Laureates

McLean Hospital Research Fellow Natalia V. Luchkina, PhD, took part in the annual Lindau Nobel Laureate Meeting in Lindau, Germany, this past June. Established in 1951, this event provides undergraduates, PhD candidates, and post-doctoral researchers with the opportunity to listen and learn from Nobel Prize recipients in fields such as physiology, medicine, physics, and chemistry. This year, the...

2018-2019 McLean Fellowship Awardees

McLean Hospital has announced the recipients of 12 fellowships for the 2018-2019 academic year. These fellowships are made possible through a combination of generous support from donors and internal funding resources. McLean Hospital is grateful to its donors, whose philanthropic investments exemplify their trust in the talented investigators listed below who are helping to advance the field of...

McLean Investigators Suggest That Specific Brain Circuits Could Unlock New Psychiatric Treatments

A McLean Hospital scientific team’s comprehensive analysis of recent research into how the brain shapes responses to cognitive and emotional challenges has revealed the potential for new brain treatments for psychiatric conditions that target specific brain circuits. The detailed review, “An Emerging Circuit Pharmacology of GABAA Receptors,” is available online in the journal Trends in...

Recent McLean Research Publications – May 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Improving adherence to Mediterranean-style diet with a community culinary coaching program: methodology development and process evaluation Polak R, Pober D, Morris A, Arieli R, Moore M, Berry E, Ziv M. The Journal of Ambulatory Care...

Opioid Addiction: Exploring Scientific Solutions

The ultimate solution to the opioid crisis is answering the question of what causes addiction and whether it is possible to treat it more effectively or even prevent it. That’s the challenge Elena H. Chartoff, PhD, is taking on in her laboratory. As director of the Neurobiology of Motivated Behavior Laboratory at McLean Hospital, she is exploring the mechanisms that connect depression and...

Recent McLean Research Publications – April 2018

McLean’s world-class researchers are published in scholarly and scientific journals on topics ranging throughout the fields of psychiatry and neuroscience. Increases in emotional intelligence after an online training program are associated with better decision-making on the Iowa Gambling Task Alkozei A, Smith R, Demers LA, Weber M, Berryhill SM, Killgore WDS. Psychological Reports. 2018 Jan 1:...

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