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The goal of the Laboratory for Early Psychosis (LEAP) Center is to develop collaborations, data systems, and methods to better understand the unique characteristics in first episode psychosis patient outcomes and treatment impacts.
The LEAP CenterTM is one of the National Institute of Mental Health’s Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults With Mental Illness (ALACRITY) Research Centers. LEAP was funded by the National Institute of Mental Health (NIMH) in May 2019.
In order to meet its goals, the LEAP Center aims to take advantage of policy changes enhancing financing for first episode psychosis, practice changes in the field, and methods developed outside of mental health.
LEAP works closely with the Massachusetts Department of Mental Health, which receives Substance Abuse and Mental Health Services Administration funds earmarked for first episode care and collects standardized data on clinical care delivery and patient outcomes through MAPNET.
A program of the Department of Psychiatry at Beth Israel Deaconess Medical Center, MAPNET is supported by a first episode psychosis technical assistance center grant from the Massachusetts Department of Mental Health. MAPNET is dedicated to the early detection and treatment of mental illness, with the goal of connecting and supporting first episode psychosis service providers in Massachusetts.
LEAP also collaborates with coordinated specialty care clinics in Massachusetts as well as policy makers/regulators, stakeholders, and first episode psychosis experts from across the country. We have a common goal of mandating, standardizing, and supporting data collection from all first episode psychosis clinics.
Participating clinics include McLean OnTrack, Massachusetts General Hospital First-Episode and Early Psychosis Program, Massachusetts Mental Health Clinic Prevention and Recovery from Early Psychosis (MMHC PREP), Cambridge Health Alliance Recovery in Shared Experience (RISE), Boston Medical Center, and Prevention in Early Psychosis West (PREP West).
In addition to its research projects, the LEAP Center includes an administrative and a methods core. The cores will support LEAP investigators and organize activities that bring together center staff, stakeholders in the community, and workers in this area from around the country and the world.
The LEAP Center will have its inaugural conference in the Spring of 2020 to highlight clinical research for stakeholders, the medical community, first episode psychosis clinics, and the public.
LEAP also has a unique built-in mechanism that gives junior investigators the ability to apply for funding for additional projects that will complement and build on the center’s activities.
The LEAP Center includes three scientific projects.
Project 1 will use the Massachusetts All Payer Claims Database to examine pathways to care and outcomes among patients within coordinated specialty care clinics and elsewhere.
Project 2 will review the data collected by the state from first episode psychosis clinics to assess and improve data collection quality, validate measures, and integrate perspectives from patients, families, clinicians, policymakers, payers, and other stakeholders.
Project 3 will define clusters of patients using longitudinal outcome data. This is the first step to understanding the unique clinical qualities (heterogeneity) of the disease. This project will also predict the cluster type for individual patients and examine the impact of coordinated specialty care treatment accounting for this clinical heterogeneity.
LEAP Center projects will have access to large amounts of data, both reported in claims databases and prospectively assessed over four years. Data collection will include comprehensive clinical measures (diagnosis, treatment, utilization, symptoms), cognition, community functioning, patient/family reports, and clinical and clinic-level measures. This will allow center investigators to conduct extensive analyses that can contribute to our understanding of heterogeneity in first episode psychosis.
Dost Öngür MD, PhD, Center Director
Dr. Öngür is the chief of the Psychotic Disorder Division at McLean Hospital. He is also the director of McLean’s Schizophrenia and Bipolar Disorder Research Program and the William P. and Henry B. Test Professor of Psychiatry at Harvard Medical School. In addition to his clinical work, he receives funding from the National Institute of Mental Health and other sources for his research using brain imaging techniques to study chemical abnormalities in patients with schizophrenia and bipolar disorder.
John Hsu, MD, MBA, Center Director
Dr. Hsu is the director of the Program for Clinical Economics and Policy Analysis at the Mongan Institute for Health Policy at Massachusetts General Hospital. He studies innovations in health care financing and delivery, and their effects on medical quality and efficiency. With a background in internal medicine, health services research and clinical epidemiology, and health care finance and management, Dr. Hsu brings clinical, population, and business perspectives to these studies. In his work, he primarily uses large automated and electronic health record data sets, often exploiting natural experiments from both clinical and behavioral economics perspectives.
Miguel Hernán, MD, DrPH, Center Director
Dr. Hernán is the Kolokotrones Professor of Biostatistics and Epidemiology at the Harvard T.H. Chan School of Public Health. He conducts research to learn what works to improve human health. Together with his collaborators, Dr. Hernán designs analyses for causal inference from healthcare databases, epidemiologic studies, and randomized trials.
The NIMH-funded Laboratory for Early Psychosis (LEAP) Center invites proposals for pilot projects.
We will award up to three scientific projects of up to $50,000 each over a 1-year period. The projects must be focused on clinical research in early psychosis and be aligned with LEAP’s goals.
Specifically, we are looking for pilot projects that leverage insights and approaches from fields outside of psychiatry to enhance the evidence base for understanding heterogeneity of outcomes in early psychosis, the impact of interventions, and the role of policymakers and other stakeholders.
Priority will be given to applications:
Awardees will present during the annual LEAP Center symposium when requested. At the 6-month mark, they will submit brief progress reports. Awardees may be asked to attend a site visit from program officers from the NIMH. Within 30 days of end of funding period, awardees will submit a 1-page report that includes a summary of the research, results, and future plans.
Applications must include:
A committee composed of LEAP Center investigators will conduct an initial review to select frontrunner applications. The principal investigators of these applications will then be asked to join an interview to discuss the research and to incorporate feedback to the design of their proposal. This iterative process will lead to the selection of up to three applications for funding.
The committee will consider off-cycle applications if these are exceptionally impactful and time-sensitive. Please contact LEAP Center staff if you are interested in submitting an off-cycle application.
The deadline for submitting applications is January 4, 2021. Awards will be announced by end of March 2021. Funding will begin May 1, 2021.
Applications should be submitted electronically to Sandra Melanson at firstname.lastname@example.org.
For more information, please call 617.855.2814.
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